Hypocretins: Waking, Arousal, or Action?
نویسندگان
چکیده
The role of hypocretin (orexin) neurotransmission in waking and arousal, though of intense interest, is poorly understood. In this issue of Neuron, demonstrate that, in general, hypocretin neurons are minimally active during both sleep and quiet waking. In contrast, these neurons display robust activity during periods of alert and/or active waking.
منابع مشابه
Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action.
The hypocretins (orexins) are a newly identified peptide family comprised of two peptides, hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides in the regulation of behavioral state. For example, these peptides are found in a variety of brain regions associated with the regulation of forebrain neuronal and behavioral activity states. Furthermore, when infu...
متن کاملArousal and reward: a dichotomy in orexin function.
The orexins (or hypocretins) are neuropeptide transmitters made exclusively in hypothalamic neurons that have extensive CNS projections. Previous studies reported that this system is most strongly associated with feeding, arousal and the maintenance of waking. We review here recent studies that reveal a novel and important role for the orexin/hypocretin neuronal system in reward processing and ...
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1011 NMDA and Sleep-Wakefulness in HCRT-KO Mice—Kostin et al. INTRODUCTION The hypocretins (HCRT-1 and 2), also called orexins, are unique hypothalamic peptides that have been implicated in many physiological functions including sleep-wake regulation.1-4 In the brain, HCRT-expressing neurons are predominantly localized in the perifornical, dorsomedial, and lateral hypothalamic area (PF-LHA).5-8...
متن کامل[Hypocretins: involvement in the regulation of sleep-wakefulness cycle and pathogenesis of narcolepsy].
Hypocretins (also called orexins) are two newly discovered neuropeptides originating from the same precursor, preprohypocretin. The amino-acid sequences of hypocretin are highly conserved among vertebrates. Cells bodies of hypocretin neurons are restricted mainly to the lateral and ventral hypothalamus, while hypocretin fibers project throughout the brain, including several areas implicated in ...
متن کاملThe orexins/hypocretins and schizophrenia.
Advances in molecular biology have led to new peptides and proteins being discovered on a regular basis, including the isolation of a number of neurotransmitter candidates. Rarely, however, do these immediately capture the attention of the scientific community. The isolation and characterization of the orexin/hypocretin peptides a decade ago resulted in a slew of studies that have helped clarif...
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عنوان ژورنال:
- Neuron
دوره 46 شماره
صفحات -
تاریخ انتشار 2005